Neglected Tropical Diseases (NTDs) can be significant drivers of mental ill-health in the people they affect as well as their families and caregivers. This good practice guide draws on CBM Global’s experience supporting Community Mental Health in NTD care to highlight the link between mental wellbeing, stigma and NTDs, and document good practice examples of how mental health support for people with NTDs can be improved and community stigma reduced. It includes examples of how CBM Global is working with partners to mainstream mental health in NTD programmes; recommendations for scaling-up initiatives that support mental health and reduce stigma of people with NTDs; and links to other resources.